Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI1B11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APCs).
Activated T cells express inhibitory receptors such as PD-1 (PDCD-1), which binds ligands PDL-1 and PDL-2 to downregulate immune activation in the absence of danger signals.
PD-1 deficiency leads to hyperactivation of the immune system and autoimmune phenotypes.
Although PD-1 has a predicted molecular weight, it often migrates at a higher apparent molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.