Thermo Fisher Scientific HCN1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic Peptide: L(875) N T D P D A E K P R F A N S L(890) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HCN1,uniProtId:Q9JKB0-1,ncbiNodeId:10114,antigenRange:875-890,antigenLength:910,antigenImageFileName:PA1-917_HCN1_Q9JKB0-1_Rabbit.svg,antigenImageFileNamePDP:PA1-917_HCN1_Q9JKB0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2115000

Product Specific Information

PA1-917 detects the HCN1 from rat samples.

PA1-917 has been successfully used in Western blot procedures. By Western blot, this antibody detects bands at ~98 kDa and ~115 kDa representing the non-glycosylated and glycosylated form of HCN1 in rat brain extract.

The PA1-917 immunizing peptide corresponds to amino acid residues 875-890 from human HCN1.

Target Information

HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.