Thermo Fisher Scientific PMCA2 ATPase Polyclonal Antibody
PMCA2 ATPase를 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Pig, Rat 등 다양한 종에서 반응합니다. Western Blot, IHC 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제된 고품질 항체입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific PMCA2 ATPase Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | 16 |
| Immunohistochemistry (IHC) | - | 8 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:200 | 1 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:20–1:200 | 1 |
| Immunocytochemistry (ICC/IF) | - | 11 |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | - | 3 |
| Functional Assay | - | 1 |
| Gel Shift (GS) | - | 1 |
| Miscellaneous PubMed | - | 1 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Pig, Rat |
| Published Species | Chicken, Hamster, Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 5–19 of human PMCA2 ATPase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% Sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2243199 |
Product Specific Information
PA1-915 detects calcium pump of the plasma membrane 2 (PMCA2 ATPase) from human, rat, and porcine tissues and cells.
It has been successfully used in Western blot procedures, detecting ~127 kDa and ~133 kDa proteins representing PMCA2a and PMCA2b ATPases from rat brain microsomal fractions.
The immunizing peptide corresponds to amino acid residues 5–19 from human PMCA2 ATPase, which is completely conserved between human and rat.
Target Information
PMCA ATPase (Plasma Membrane Calcium ATPase) pumps calcium from the cytosol to the extracellular space. This enzyme is related to other ATPases such as SERCA and Na⁺/K⁺ pumps.
There are four genes encoding PMCA ATPase, with about 20 isoforms generated through alternative splicing.
Isoform expression is tissue-specific: PMCA1 and PMCA4 are broadly expressed, while PMCA2 and PMCA3 are more restricted.
In the pancreas, β cells express only the 4b isoform, whereas α and γ cells express both 4a and 4b isoforms.
Different splice variants exhibit distinct affinities for calcium and calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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