Thermo Fisher Scientific c-Met Monoclonal Antibody (eBioclone 97), FITC, eBioscience

Thermo Fisher Scientific c-Met Monoclonal Antibody (eBioclone 97), FITC, eBioscience™

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (1 µg)/test
Publications: View 6 publications

Product Specifications

Product Specific Information

The eBioclone 97 monoclonal antibody was generated against a human c-Met-Ig fusion protein and reacts with human c-Met (HGFR)-transfected cells.
Human c-Met is a 145 kDa receptor tyrosine kinase expressed by epithelial cells in the brain, kidney, liver, and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation and activation of downstream effectors such as ERK-1, ERK-2, and PLCγ.
Activation of the c-Met pathway induces cellular responses including motility, scattering, proliferation, survival, and angiogenesis. Mutations in c-Met are implicated in various malignancies.

Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Pre-titrated and tested on A549 cells at 5 µL (1 µg) per test (final volume 100 µL).
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

MET (cMET) is a receptor-like tyrosine kinase involved in signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
It plays roles in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and adult processes (wound healing, organ regeneration, tissue remodeling).
Dysregulation of MET is linked to cancers including gastric, renal, and breast, making it a key target for cancer research and diagnostics.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지