Thermo Fisher Scientific c-Met Monoclonal Antibody (eBioclone 7), FITC, eBioscience
FITC로 표지된 Thermo Fisher Scientific eBioclone 7 c-Met 단클론 항체로, 마우스 c-Met에 특이적으로 반응하며 Flow Cytometry에 최적화됨. 488 nm 청색 레이저 사용, 0.5 mg/mL 농도. 연구용으로만 사용 가능.
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Thermo Fisher Scientific c-Met Monoclonal Antibody (eBioclone 7), FITC, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1 µg/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioclone 7 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_494114 |
Additional Formats
Product Specific Information
The eBioclone 7 monoclonal antibody was generated against a mouse c-Met-Ig fusion protein and reacts with mouse c-Met-transfected cells.
Mouse c-Met (HGFR) is a 170 kDa receptor tyrosine kinase expressed by epithelial cells of the brain, kidney, liver, and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation and activation of downstream effectors including ERK-1, ERK-2, and PLCγ.
Activation of the c-Met signal transduction pathway leads to cellular responses such as motility, scattering, proliferation, survival, and angiogenesis.
Mutations in human c-Met are implicated in several malignancies.
Applications Reported:
This eBioclone 7 antibody has been reported for use in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of mouse c-Met-transfected 293T cells. Recommended usage ≤ 1 µg per test (100 µL final volume).
Cell number can range from 10⁵ to 10⁸ cells/test.
Careful titration is recommended for optimal assay performance.
Optical Properties:
- Excitation: 488 nm
- Emission: 520 nm
- Laser: Blue Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation is associated with various human cancers. Upon activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, triggering signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET plays roles in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and adult processes (wound healing, organ regeneration, tissue remodeling).
Aberrant MET activity is linked to gastric, renal, and breast cancers, making it a key target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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