Thermo Fisher Scientific Spectrin beta III (SPTBN2) Monoclonal Antibody (rSPTBN2/1778)
Spectrin beta III(SPTBN2)에 특이적인 단클론 항체로 Western blot, ELISA, Peptide Array에 사용 가능. 인간 단백질 반응성, 마우스 IgG1 아이소타입. Protein A/G 정제, 4°C 보관. 신경세포 골격 단백질 연구용.
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- 6712-MSM10-Px (2개 옵션)
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| ELISA | 2–4 µg/mL |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rSPTBN2/1778 |
| Immunogen | Recombinant fragment (around aa356–475) of human SPTBN2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Spectrins are principal components of a cell’s membrane–cytoskeleton and are composed of two alpha and two beta spectrin subunits.
The protein encoded by the SPTBN2 gene is called spectrin beta non-erythrocytic 2 (beta-III spectrin).
It is related to, but distinct from, the beta-II spectrin gene (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in this gene cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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