Thermo Fisher Scientific Spectrin beta III (SPTBN2) Monoclonal Antibody (rSPTBN2/1778)
Human SPTBN2 단백질을 인식하는 mouse monoclonal antibody. Western blot, ELISA, Peptide Array에 사용 가능. Protein A/G로 정제된 액상 항체로, PBS(pH 7.4)에 보존제 없이 제공. -20°C 보관, 동결/해동 반복 피할 것.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| ELISA | 2–4 µg/mL |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rSPTBN2/1778 |
| Immunogen | Recombinant fragment (around aa356–475) of human SPTBN2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Spectrins are principal components of the cell membrane–cytoskeleton, composed of two alpha and two beta spectrin subunits.
The SPTBN2 gene encodes spectrin beta non-erythrocytic 2 (beta-III spectrin), which is distinct from the beta-II spectrin (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in SPTBN2 are associated with spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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