Thermo Fisher Scientific Parvalbumin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-1 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

5-10 µg/mL

-

ELISA (ELISA)

0.05-0.2 µg/mL

-

Immunoprecipitation (IP)

2-10 µg/mg of lysate

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Purified His-tagged human Parvalbumin (Swiss Prot: P20472) full length recombinant protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

Product Specific Information

Reconstitute the lyophilized powder with deionized water (or equivalent) to antibody concentration of 0.5 mg/ml.

Parvalbumin (PV) is a calcium binding protein. It belongs to a larger group of EF hand proteins and consists of a single, unbranched chain of linked amino acids. Parvalbumin participates in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. And it is implicated in maintaining the balance between excitation and inhibition in the cortex as well as in the hippocampus. It is also expressed in specific muscle fibers and fast-firing neurons.GenScript Rabbit Anti-Parvalbumin Polyclonal Antibody is developed in rabbit using purified His-tagged human Parvalbumin (Swiss Prot: P20472) full length recombinant protein.

Target Information

Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.