Thermo Fisher Scientific CD18 Monoclonal Antibody (WT.3)
Rat CD18 단백질을 표적하는 Mouse IgG1 단클론 항체로, FACS, IP, WB, ELISA 등 다양한 분석에 적합합니다. 저엔도톡신 제형으로 고순도 Protein G 정제 제품이며, 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1 µg/test | View 3 publications |
| ELISA | - | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WT.3 |
| Immunogen | Rat beta2 Integrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_223590 |
Product Specific Information
MA1817 targets CD18 in FACS, IP, and WB applications and shows reactivity with rat samples.
The immunogen is rat beta2 Integrin.
MA1817 detects CD18 with a predicted molecular weight of approximately 83 kDa.
This product is a Low Endotoxin formulation.
Tested for endotoxins by LAL assay, containing ≤10 EU/mg endotoxin concentration.
Target Information
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes.
CD18 combines with integrin molecules CD11a–CD11d to form heterodimers (αLβ2, αMβ2, αXβ2, αDβ2), which mediate cell adhesion and signaling.
Absence or reduction of CD18 expression leads to leukocyte adhesion deficiency-1 and related immune dysfunctions.
CD18 also mediates leukotoxin-induced cytolysis by Mannheimia haemolytica.
Two transcript variants encoding CD18 protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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