Thermo Fisher Scientific CD45 Monoclonal Antibody (OX-1), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: Neat-1:10

Product Specifications

Additional Formats

• Unconjugated: MA1-81566
• Request custom conjugation available

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Mouse anti-Rat CD45 antibody, clone OX-1 recognizes CD45, also known as the leucocyte common antigen (LCA).

Target Information

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising approximately 10% of lymphocyte surface proteins.
It is absent on non-hematopoietic cell lines and tissues. CD45 glycoprotein is essential in lymphocyte development and antigen signaling, regulating Src-family kinases and JAK kinases.
CD45 isoforms differ due to alternative splicing, affecting extracellular domains and expression patterns among lymphoid subtypes.
It plays a critical role in T- and B-cell receptor signaling, cytokine receptor regulation, and integrin-mediated signal transduction related to cell survival and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지