Thermo Fisher Scientific CD31 Monoclonal Antibody (LCI-4), APC

Thermo Fisher Scientific CD31 Monoclonal Antibody (LCI-4), APC

Applications

• Flow Cytometry (Flow)

Tested Dilution: Neat-1:10
Publications: View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store undiluted at 4ºC in the dark.
• Shelf life after reconstitution: approx. 18 months.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
• Mouse anti-Pig CD31, clone LCI-4 recognizes porcine CD31 (PECAM-1).

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling through ITIM motifs that recruit protein-tyrosine phosphatases upon phosphorylation.
CD31 is expressed throughout the vascular compartment, mainly at junctions between adjacent cells.
Its N-terminal Ig-like domain mediates homophilic binding, facilitating cell-cell interactions.
CD31 plays roles in:

• Integrin-mediated cell adhesion
• Transendothelial migration
• Angiogenesis
• Apoptosis
• Immunoreceptor signaling regulation
• Autoimmunity and thrombosis control

For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.

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