Thermo Fisher Scientific HLA-DQ Monoclonal Antibody (SK10), APC, eBioscience
인간 HLA-DQ 분자를 인식하는 SK10 단클론 항체로, APC 형광체가 결합된 형태입니다. 항원제시세포의 MHC 클래스 II 분석에 적합하며, 유세포분석용으로 사전 희석 및 검증되었습니다. 633–647 nm 레이저에서 최적 발광하며 연구용으로 사용됩니다.
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Thermo Fisher Scientific HLA-DQ Monoclonal Antibody (SK10), APC, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.5 µg)/test
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SK10 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573319 |
Product Specific Information
This SK10 monoclonal antibody reacts with the human MHC Class II HLA-DQ molecule.
HLA-DQ is a heterodimeric cell surface receptor composed of alpha (HLA-DQA1) and beta (HLA-DQB1) subunits, expressed on antigen-presenting cells such as B cells, monocytes, macrophages, dendritic cells, and activated T cells.
It plays a key role in presenting peptide antigens to CD4+ T lymphocytes. Certain HLA-DQ alleles are associated with celiac disease and type I diabetes.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and validated for flow cytometry using normal human peripheral blood cells.
Recommended use: 5 µL (0.5 µg) per test (100 µL final volume).
Cell number: 10⁵–10⁸ cells/test (empirically determined).
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
HLA-DQ is a member of the human leukocyte antigen (HLA) class II family of MHC surface proteins.
These heterodimeric molecules consist of an alpha (DQA) and beta (DQB) chain anchored in the membrane. They present extracellularly derived peptides to immune cells and are expressed on antigen-presenting cells (APC) such as B lymphocytes, dendritic cells, and macrophages.
Other human MHC class II molecules include HLA-DP, HLA-DM, HLA-DR, HLA-DOA, and HLA-DOB.
HLA-DQ shows high polymorphism, especially in the beta subunit, influencing peptide binding and serotype classification.
HLA and MHC antibodies are essential tools in Immunopeptidomics, enabling identification and characterization of neoantigens via high-performance liquid chromatography coupled with tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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