Thermo Fisher Scientific BRD7 Recombinant Rabbit Monoclonal Antibody (BLR221K)
BRD7 단백질을 표적으로 하는 재조합 토끼 단일클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry, IP 등 다양한 분석에 사용 가능. HEK293F 발현 시스템에서 생산된 고순도 항체이며, 1 mg/mL 농도로 BBS buffer에 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific BRD7 Recombinant Rabbit Monoclonal Antibody (BLR221K)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR221K |
| Immunogen | Peptide representing a region between residue 601 and the C-terminus (residue 651) of Human Bromodomain-containing protein 7 (BRD7, UniProt ID: Q9NPI1-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BRD7 acts both as coactivator and as corepressor. It activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating GSK3B phosphotransferase activity. It is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, facilitating recruitment of TP53 to target promoters and inhibiting cell cycle progression from G1 to S phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: A700-221CF_BRD7_Q9NPI1-1_Rabbit.svg, A700-221CF_BRD7_Q9NPI1-1_Rabbit_PDP.jpeg)
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