Thermo Fisher Scientific NOTCH 2 Polyclonal Antibody
NOTCH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ELISA, IP 등 다양한 실험에 사용 가능. 사람, 개, 침팬지 반응성 확인. 고농도(75 mg/mL) 액상 형태로 안정적이며 -20°C 보관 권장.
- 카탈로그번호
- 100-401-406
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
| ELISA | 1:30,000–1:90,000 |
| Immunoprecipitation (IP) | 1:400–1:2,000 |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Dog, Chimpanzee, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to internal region near amino acid residues 2390–2415 of human Notch 2 (total protein 2471 aa). A cysteine residue added to N-terminal end for coupling. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 75 mg/mL |
| Storage Buffer | 0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as undiluted liquid. Dilute only prior to immediate use.
This antiserum is directed against human NOTCH2. The peptide sequence shows 100% alignment with human, dog, and chimpanzee sequences. Only one non-conservative amino acid difference is found in mouse. Expected to react with rat and mouse NOTCH2. No specific data for other species.
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved receptor in the Notch signaling pathway. It is a type I transmembrane protein with multiple EGF-like repeats in its extracellular domain and diverse domains in its intracellular region.
NOTCH2 interacts with ligands Jagged1, Jagged2, and Delta1 to regulate cell fate determination.
Defects in NOTCH2 cause Alagille syndrome type 2 (ALGS2), an autosomal dominant disorder characterized by hepatic bile duct paucity, cholestasis, and cardiac, skeletal, and ophthalmologic abnormalities. Facial features are characteristic, and renal/vascular involvement may occur.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(원본 이미지 파일명: 100-401-406_NOTCH2_Q04721-1_Rabbit.svg, 100-401-406_NOTCH2_Q04721-1_Rabbit_PDP.jpeg)
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