Thermo Fisher Scientific Angiopoietin 2 Polyclonal Antibody
Thermo Fisher Scientific의 Angiopoietin 2 Polyclonal Antibody는 인간 및 마우스 단백질에 반응하며 다양한 면역분석(WB, IHC, ICC, ELISA, IP)에 적합합니다. 고농도(80 mg/mL) 액상 형태로 제공되며, 안정적인 저장(-20°C) 및 높은 특이성을 갖춘 연구용 항체입니다.
- 카탈로그번호
- 100-401-402x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Angiopoietin 2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| ELISA | 1:5,000–1:25,000 |
| Immunoprecipitation (IP) | 1:500–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-Angiopoietin 2 antiserum prepared by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminus of mouse angiopoietin-2 protein, conjugated to KLH using maleimide. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 80 mg/mL |
| Storage Buffer | 0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
Angiopoietin 2 Antibody antiserum is directed against mouse angiopoietin-2 and shows no reactivity with angiopoietin-1 from mouse-derived proteins.
This reagent cross-reacts with human angiopoietin-2, and partial cross-reactivity is noted with human angiopoietin-1.
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2 but, unlike ANG-1, does not induce tyrosine phosphorylation.
Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act either as an agonist or antagonist of Tie-2–induced angiogenesis depending on the physiological environment.
The signaling interactions of ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are required for embryonic and adult angiogenesis.
Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acid residues, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain, predominantly existing as a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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