Thermo Fisher Scientific Angiopoietin 2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

Angiopoietin 2 Antibody antiserum is directed against mouse angiopoietin-2 and shows no reactivity with angiopoietin-1 from mouse-derived proteins.
This reagent cross-reacts with human angiopoietin-2, and partial cross-reactivity is noted with human angiopoietin-1.

Target Information

ANG-2 binds to the endothelial cell-specific receptor Tie-2 but, unlike ANG-1, does not induce tyrosine phosphorylation.
Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act either as an agonist or antagonist of Tie-2–induced angiogenesis depending on the physiological environment.
The signaling interactions of ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are required for embryonic and adult angiogenesis.
Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acid residues, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain, predominantly existing as a disulfide-linked dimer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.