Thermo Fisher Scientific POMC Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

1:2,000

-

Product Specifications

Species Reactivity

Human, Sheep

Host/Isotype

Guinea pig / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to the amino acids 77 - 88 from human POMC, conjugated to carrier protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:POMC,uniProtId:P01189-1,ncbiNodeId:9606,antigenRange:77-88,antigenLength:267,antigenImageFileName:PA1-18411_POMC_P01189-1_Guinea_pig.svg,antigenImageFileNamePDP:PA1-18411_POMC_P01189-1_Guinea_pig_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10981079

Product Specific Information

Reconstitute in 50 µL sterile water. Centrifuge to remove any insoluble material. It is recommended that a thawed sample is stored at 4 °C for no longer than 2 weeks. Allocation of appropriate anti-bacterial agent can increase shelf life by several weeks. Diluted serum should be prepared as required. Long term stability requires storage, preferably in small aliquots at -20 °C or lower. Glycerol (1:1) can be added to neat serum for additional stability if intended use does not prevent this.

Target Information

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.