Thermo Fisher Scientific PEDF Polyclonal Antibody
PEDF 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA 등에 사용 가능. 인간 및 마우스 반응성, 고순도 친화 크로마토그래피 정제. 신경보호 및 항혈관신생 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 141–240 of human PEDF/SERPINF1 (NP_0026063) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.89 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914055 |
Product Specific Information
Positive test controls include:
- HepG2
- Mouse liver
- Human serum
Target localization:
- Melanosome
- Secreted
Immunogen sequence:
RIVFEKKLRI KSSFVAPLEK SYGTRPRVLT GNPRLDLQEI NNWVQAQMKG KLARSTKEIP DEISILLLGV AHFKGQWVTK FDSRKTSLED FYLDEERTVR
Target Information
PEDF (Pigment Epithelium-Derived Factor) is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body.
Key characteristics:
- Induces apoptosis in proliferating endothelial cells
- Inhibits angiogenic factors (VEGF, FGF-2)
- Exhibits neuroprotective effects by suppressing neuronal apoptosis
- Interacts with PEDF-R, a high-affinity lipase-linked receptor
PEDF is a potential therapeutic target for:
- Age-related macular degeneration (AMD)
- Proliferative diabetic retinopathy (PDR)
- Angiogenesis-related cancers
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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