Thermo Fisher Scientific CD23 Monoclonal Antibody (EBVCS2), FITC, eBioscience
인간 CD23 항원을 인식하는 EBVCS2 클론의 단클론 항체로, FITC 형광 표지되어 있습니다. Flow Cytometry 및 동결 조직 면역조직화학에 적합하며, IgE 반응 및 B 세포 활성 조절 연구에 활용됩니다. 488 nm/520 nm 형광 특성, 4°C 보관.
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Thermo Fisher Scientific CD23 Monoclonal Antibody (EBVCS2), FITC, eBioscience
Applications and Tested Dilution
- Immunohistochemistry (Frozen): Assay-dependent
- Flow Cytometry: 5 µL (0.25 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EBVCS2 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572444 |
Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- Brilliant UV 805
- eFluor 450
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Red 685
- NovaFluor Red 700
- NovaFluor Red 755
- NovaFluor Yellow 610
- NovaFluor Yellow 660
- NovaFluor Yellow 700
- NovaFluor Yellow 755
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation available
Product Specific Information
The EBVCS2 monoclonal antibody reacts with human CD23, a 45 kDa type II transmembrane glycoprotein. CD23 is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at low levels on T cells, NK cells, Langerhans cells, and platelets. Expression of CD23 is upregulated upon B cell activation, and soluble forms of the antigen are biologically active.
CD23 serves as a low-affinity receptor for IgE and plays a role in IgE response regulation and B cell activation. CD21 and the α subunit of CD11b/CD11c bind to CD23.
- Applications Reported: Flow cytometric analysis and immunohistochemical staining of frozen tissue sections
- Applications Tested: Pre-titrated and tested by flow cytometry using normal human peripheral blood cells. Recommended usage is 5 µL (0.25 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
- Excitation: 488 nm
- Emission: 520 nm
- Laser: Blue Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD23 is a 45 kDa glycoprotein present on a subpopulation of peripheral blood and tonsil B cells, and strongly expressed on EBV-transformed B lymphoblasts. It is identical to the low-affinity IgE receptor found on B cells. CD23 expression has been detected in neoplastic cells from chronic lymphocytic leukemia and certain lymphomas. Functionally, CD23 is involved in B cell growth, differentiation, and IgE production. Its soluble form acts as a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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