Thermo Fisher Scientific CD23 Monoclonal Antibody (B3B4), FITC, eBioscience

Thermo Fisher Scientific CD23 Monoclonal Antibody (B3B4), FITC, eBioscience

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 0.5 µg/test
• Publications: View 27 publications

Product Specifications

Available Formats

• Unconjugated
• Biotin
• Brilliant UV 805
• eFluor 450
• eFluor 660
• NovaFluor Blue 510
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Red 685
• NovaFluor Red 710
• NovaFluor Red 725
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• NovaFluor Yellow 755
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Super Bright 645
• Request custom conjugation

Product Specific Information

The B3B4 monoclonal antibody reacts with mouse CD23, a 45 kDa type II transmembrane glycoprotein expressed on resting conventional B cells. Its expression is modulated upon B-cell activation, while B-1 lineage (CD5+ B cells) does not express CD23. Soluble forms are biologically active and serve as low affinity receptors for IgE, playing roles in IgE response regulation and B-cell activation. CD21 is known to bind CD23.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Tested on mouse splenocytes, ≤0.5 µg/test
• Recommended Use: Titrate for optimal performance
• Excitation: 488 nm
• Emission: 520 nm
• Laser: Blue Laser
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD23 is a 45 kDa glycoprotein found on a subpopulation of peripheral blood and tonsil B cells, strongly expressed on EBV-transformed B lymphoblasts. It acts as a low-affinity IgE receptor and is involved in B cell growth, differentiation, and IgE production. Soluble CD23 functions as a potent mitogenic factor. Abnormal CD23 expression is associated with diseases such as chronic conjunctivitis and chronic lymphocytic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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