Thermo Fisher Scientific GPR132 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 10 µg/mL
• For IHC(P), use proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human (100%), Gorilla (83%), Marmoset (83%)

Target Information

GPR132 (also known as GPCR G2A) is a G-protein linked receptor for lysophosphatidylcholine (LPC). It may act as a sensor of LPC levels at sites of inflammation, helping limit tissue infiltration and progression to autoimmune disease. Functions at the G2/M checkpoint to delay mitosis and may assist T and B cells in slowing proliferation and repairing damaged DNA. Highly expressed in macrophages and lymphocyte-rich tissues such as spleen and thymus, with weak expression in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and shoulder region. Induced by DNA-damaging agents.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.