Thermo Fisher Scientific TEM5 Polyclonal Antibody
인간 TEM5 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며 PBS 버퍼에 0.1% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품.
- 카탈로그번호
- PA532794
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 11 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR124 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550256 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Gibbon, Monkey (90%); Dog (85%) - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogenesis, which are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7, and TEM8.
TEM5 is a member of the adhesion family of G protein-coupled receptors and is localized on the surface of endothelial cells. Unlike TEM1, TEM7, and TEM8, TEM5 is a seven-pass transmembrane receptor. It is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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