Thermo Fisher Scientific Human TIM-1 Synthetic Peptide
인간 TIM-1 단백질의 N-말단 16개 아미노산 서열로 구성된 합성 펩타이드. TIM-1 항체(PA5-20244)와 함께 차단 실험에 사용 가능. 정제된 액상 형태로 PBS(pH 7.2)와 0.1% BSA, 0.02% sodium azide 포함. -20°C에서 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human TIM-1.
PEP-0363 can be used as a blocking peptide with polyclonal antibody PA5-20244.
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
Its endogenous ligand is Tim-4. CD365 functions as a receptor or co-receptor for several viruses, including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses, through binding to phosphatidylserine exposed on viral envelopes.
Polymorphisms in the human CD365 gene (HAVCR1) are linked to infection susceptibility and disease severity. CD365 also plays a role in T cell co-stimulation and is primarily expressed in epithelial cells, including A549, 769-P, and Caco-2 cell lines.
A soluble form of CD365 can be generated by metalloproteinase-mediated proteolytic cleavage of the surface protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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