Thermo Fisher Scientific Cullin 3 Polyclonal Antibody
Rabbit polyclonal antibody targeting Cullin 3, reactive with human, mouse, rat, and primate. Validated for Western blot (1:1,000). Supplied as a liquid, unconjugated form, purified by antigen affinity chromatography. For research use only.
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Applications
- Western Blot (WB): 1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Leu750 of human Cullin-3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 32 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985263 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Cullin 3 is a member of the human cullin gene family (CUL1, 2, 3, 4a, 4b, and 5), homologous to the S. cerevisiae cdc53 gene.
CUL1 forms a complex with human p19 skp1 and F box protein p45 skp2. Together with cdc53 (known as Cul A), these three subunits form a ubiquitin ligase that controls the proteolysis of G1 cell cycle regulatory proteins.
In contrast, CUL2 does not associate with p19 skp1 and p45 skp2 but instead forms a complex with the inactive transcriptional elongation complex SIII, composed of Elongin C, Elongin B, and VHL. The function of this association remains unknown.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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