Thermo Fisher Scientific CLN6 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CLN6 protein. Validated for WB and IHC(P) applications. Detects endogenous CLN6 involved in lysosomal function. Supplied in liquid form with 1 mg/mL concentration. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human CLN6 (amino acids 238–259, UniProt ID: Q9NWW5-1, length: 311 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635459 |
Product Specific Information
This antibody detects endogenous levels of total CLN6 protein.
Target Information
CLN6 is a 311-amino acid protein with seven predicted transmembrane domains, conserved across vertebrates. It localizes to the endoplasmic reticulum and contributes to lysosomal function. Mutations in the CLN6 gene cause variant late-onset infantile neuronal ceroid lipofuscinosis (vLINCL), a lysosomal storage disorder characterized by progressive mental deterioration and blindness. CLN6 is one of eight proteins (CLN1–8) associated with neuronal ceroid lipofuscinoses (NCL), a group of severe inherited neurodegenerative disorders affecting children due to lysosomal storage material accumulation and neuronal death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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