Thermo Fisher Scientific CTLA-4 Monoclonal Antibody (CT.E8)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

CTLA-4 (cytotoxic T-lymphocyte-4, designated CD152) is a type I transmembrane T cell inhibitory molecule belonging to the Ig superfamily. CTLA-4 is recruited from intracellular vesicles to the immunological synapse 1–2 days after T cell activation. It forms a linear lattice with B7-1 on antigen-presenting cells (APCs), inducing negative regulatory signals and terminating T cell activation.

Target Information

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor primarily expressed on CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells) but with higher affinity. Unlike CD28, which enhances T cell activation, CTLA4 inhibits T cell function. Intracellular CTLA4 is also found in regulatory T cells and may play a key role in their immunoregulatory function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.