Thermo Fisher Scientific CTLA-4 Monoclonal Antibody (CT.E8)
CTLA-4 단백질을 표적으로 하는 마우스 단클론 항체로, Flow Cytometry, ELISA, Blocking Assay 등에 사용됩니다. 재조합 인간 CTLA4-Fc를 면역원으로 제작되었으며, 동결건조 형태로 제공되어 -20°C 이하에서 보관 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 2–10 µg/mL |
| ELISA | 0.01–0.1 µg/mL |
| Blocking Assay (BLOCK) | 10–50 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CT.E8 |
| Immunogen | Recombinant human CTLA4-Fc (Z03373) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
Product Specific Information
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
CTLA-4 (cytotoxic T-lymphocyte-4, designated CD152) is a type I transmembrane T cell inhibitory molecule belonging to the Ig superfamily. CTLA-4 is recruited from intracellular vesicles to the immunological synapse 1–2 days after T cell activation. It forms a linear lattice with B7-1 on antigen-presenting cells (APCs), inducing negative regulatory signals and terminating T cell activation.
Target Information
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor primarily expressed on CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells) but with higher affinity. Unlike CD28, which enhances T cell activation, CTLA4 inhibits T cell function. Intracellular CTLA4 is also found in regulatory T cells and may play a key role in their immunoregulatory function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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