Thermo Fisher Scientific Phospho-Amyloid Precursor Protein (Thr729) Polyclonal Antibody
APP 단백질의 Thr729 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 1 mg/mL 액상 형태로 PBS/glycerol buffer에 보관. 알츠하이머 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human APP (Accession P05067), corresponding to amino acid residues around phosphorylated Thr729 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903268 |
Product Specific Information
This antibody detects endogenous levels of APP only when phosphorylated at Thr729.
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1. It is involved in neurite growth, neuronal adhesion, and axonogenesis. APP is a 100–140 kDa transmembrane glycoprotein with multiple isoforms resulting from alternative splicing. Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the main component of senile plaques, a hallmark of Alzheimer’s disease. Abnormal APP regulation is also associated with Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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