Thermo Fisher Scientific Phospho-AP2M1 (Thr156) Polyclonal Antibody
Phospho-AP2M1 (Thr156) 폴리클로날 항체로, 인산화된 AP2M1 단백질의 Thr156 부위를 특이적으로 인식합니다. Western blot 및 IHC(P) 응용에 적합하며, 사람, 생쥐, 랫드에 반응합니다. 고순도 정제 및 안정한 PBS/glycerol buffer로 제공됩니다.
- 카탈로그번호
- PA5118767
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AP2M1 (Accession Q96CW1), corresponding to amino acid residues around phosphorylated Thr156. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903267 |
Product Specific Information
This antibody detects endogenous levels of AP2M1 only when phosphorylated at Thr156.
Target Information
The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family.
The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, responsible for proton pumping in the acidification of endosomes and lysosomes.
AP2M1 associates with the HIV-1 protein Nef, suggesting that Nef may use the AP-2 complex to enhance the endocytosis rate of CD4 and class I MHC.
AP2M1 may also play an important role in regulating intracellular trafficking and the function of CTLA-4 protein.
At least two isoforms of AP2M1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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