Thermo Fisher Scientific Integrin beta 7 Monoclonal Antibody (473207), PE
인테그린 베타 7을 인식하는 마우스 모노클로날 항체로, PE 형광 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 인간 시료에 반응하며, 단백질 A/G로 정제되었습니다. 4°C에서 암소 보관하며 동결 금지입니다.
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Applications
- Flow Cytometry (Flow): 10 µL per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 473207 |
| Immunogen | CHO-derived recombinant human Integrin beta 7 long isoform (Glu20–His723) |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | Buffered saline solution with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609113 |
Additional Formats
Product Specific Information
In Western blots, no cross-reactivity with recombinant human Integrin beta 1, beta 2, beta 3, beta 4, beta 5, beta 6, beta 8, recombinant mouse Integrin beta 4, or beta 7 is observed.
Target Information
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin (LPAM-1), expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin (HML-1), expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes.
Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1, and fibronectin, while the ligand of HML-1 is E-cadherin (CD324).
Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells, promoting transmigration of leukocytes to extravascular spaces during inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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