Thermo Fisher Scientific CD138 Monoclonal Antibody (359103), APC

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

10 µL per million cells

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

359103

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Syndecan-1/CD138 Gln18-Glu251 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD138 (Syndecan-1),uniProtId:P18827-1,ncbiNodeId:9606,antigenRange:18-251,antigenLength:310,antigenImageFileName:MA5-23540_CD138_Syndecan-1_P18827-1_Rat.svg,antigenImageFileNamePDP:MA5-23540_CD138_Syndecan-1_P18827-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

Buffered saline solution with BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609283

Product Specific Information

In direct ELISAs, this antibody shows approximately 60% cross-reactivity with recombinant mouse (rm) Syndecan-1 and no cross-reactivity with recombinant human (rh) Syndecan-2, rhSyndecan-3, or rmSyndecan-4.

Target Information

CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.