Thermo Fisher Scientific PDE6 Gamma Polyclonal Antibody, FITC
FITC로 표지된 PDE6 Gamma 폴리클로날 항체로 Western blot, ELISA, IP에 적합. 소, 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제. 시그널 전달 경로 연구용으로 최적화된 연구용 시약.
- 카탈로그번호
- PD6G-FITC
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific PDE6 Gamma Polyclonal Antibody, FITC
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic cyclic peptide common to all PDE6 gamma variants |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The second messengers cAMP and cGMP are key regulatory molecules involved in various signal transduction pathways. Their levels are controlled by synthesis via nucleotide cyclases and hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDE6 acts as the effector enzyme in the G protein-mediated visual signal transduction cascade. It comprises rod and cone-specific catalytic subunits (alpha, alpha, beta), an inhibitory gamma subunit, and a delta subunit of unknown function. The catalytic core consists of alpha/alpha` homodimers in cones and alpha/beta heterodimers in rods. The C-terminus of both catalytic and inhibitory subunits undergoes methylation, myristoylation, and prenylation, essential for proper complex assembly and membrane association.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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