Thermo Fisher Scientific PDE6 Gamma Polyclonal Antibody, Biotin
PDE6 Gamma 단백질을 인식하는 Biotin 결합 Rabbit Polyclonal 항체로, Western blot, ELISA, IP에 적합. 인간, 생쥐, 랫트, 소 등 다양한 종에 반응. 고순도 Affinity chromatography로 정제되어 안정적인 신호 검출에 유용. 연구용 전용 제품.
- 카탈로그번호
- PD6G-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic cyclic peptide common to all PDE6 gamma variants |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The second messengers cAMP and cGMP are key regulatory molecules involved in diverse signal transduction pathways. Their levels are controlled by synthesis via nucleotide cyclases and hydrolysis by cyclic nucleotide phosphodiesterases (PDEs).
PDEs form a superfamily of enzymes that convert 3′,5′-cyclic nucleotides to nucleoside 5′-monophosphates.
PDE6 acts as the effector enzyme in the G protein-mediated visual signal transduction cascade. It comprises five subunits:
- Catalytic subunits (α′ for cone, α and β for rod)
- Inhibitory subunit (γ)
- Delta subunit (δ) of unknown function
The catalytic core consists of α′/α′ homodimers (cone) and α/β heterodimers (rod). The C-terminus of both catalytic and inhibitory subunits undergoes methylation, myristoylation, and prenylation, essential for proper complex assembly and membrane association.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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