Thermo Fisher Scientific mGluR1 Polyclonal Antibody
Rabbit polyclonal antibody targeting mGluR1 for IHC(P) applications. Reacts with bovine, human, and rabbit species. High purity via antigen affinity chromatography. Supplied as liquid, 1 mg/mL in PBS with sodium azide. Ideal for neuroscience receptor s...
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Thermo Fisher Scientific mGluR1 Polyclonal Antibody
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 17 µg/mL
Publications
- [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM1 / MGLUR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551182 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Elephant, Panda, Bovine, Rabbit (100%).
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. Traditionally, it was known to act on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors, which mediate fast excitatory synaptic transmission. More recently, glutamate has been shown to regulate enzymes producing second messengers via specific G-protein-coupled receptors known as metabotropic glutamate receptors (mGluRs).
Group-I receptors (mGluR1a and mGluR5) stimulate phospholipase C, increasing phosphoinositide turnover and calcium release from internal stores. Group-II (mGluR2, mGluR3) and Group-III receptors inhibit adenylyl cyclase activity.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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