Thermo Fisher Scientific mGluR1 Polyclonal Antibody
Rabbit polyclonal antibody targeting mGluR1 for IHC(P) applications. Reacts with human and non-human primate species. Antigen affinity purified and supplied in PBS with 0.1% sodium azide. Suitable for neuroscience and receptor signaling research.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]: 14–28 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from C-terminus of human GRM1 / mGluR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551183 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset (100%).
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels such as NMDA, AMPA, and kainate receptors, which mediate fast excitatory synaptic transmission.
Additionally, glutamate regulates enzymes producing second messengers via G-protein-coupled metabotropic glutamate receptors (mGluRs).
- Group I receptors (mGluR1a, mGluR5): Stimulate phospholipase C, increasing phosphoinositide turnover and calcium release.
- Group II and III receptors (mGluR2, mGluR3): Inhibit adenylyl cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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