Thermo Fisher Scientific PEDF Polyclonal Antibody
PEDF 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from mouse PEDF (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PEDF (Pigment Epithelium-Derived Factor) is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties.
It is a 50 kDa glycoprotein secreted by various tissues. PEDF induces apoptosis in proliferating endothelial cells and inhibits angiogenic factors such as VEGF and FGF-2.
Its neuroprotective effects are mediated by suppression of neuronal apoptosis induced by oxidative stress or neurotoxins.
PEDF binds to a lipase-linked receptor (PEDF-R), the only known signaling receptor used by a serpin family member.
PEDF is a potential therapeutic target for neurodegenerative and angiogenesis-related diseases including AMD, PDR, and certain cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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