Thermo Fisher Scientific Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular and Histiocytic Marker) Monoclonal Antibody (AAT/4615)
인간 SERPINA1 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 및 펩타이드 어레이에 적합합니다. 간세포암 및 조직구종 양성 대조군에 사용 가능하며, 세포질에 위치한 알파-1-안티트립신을 검출합니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AAT/4615 |
| Immunogen | Recombinant fragment (around aa200–400) of human SERPINA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Hepatocellular carcinoma or histiocytoma (IHC)
- Cellular Location: Cytoplasm
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
Deficiency of Alpha-1-AT can lead to chronic obstructive lung disease (emphysema), hepatic cirrhosis in infants, and respiratory distress in newborns.
Elevated levels occur as an acute phase response to tissue necrosis and inflammation and are observed in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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