Thermo Fisher Scientific Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular and Histiocytic Marker) Monoclonal Antibody (AAT/4613)
인간 SERPINA1(Alpha-1-Antitrypsin)을 인식하는 마우스 단클론 항체입니다. IHC(P)에서 1–2 µg/mL로 사용 가능하며, 간세포 및 조직구 마커 연구에 적합합니다. 단백질 A/G 정제, 액상 형태로 4°C 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AAT/4613 |
| Immunogen | Recombinant fragment (around aa200–400) of human SERPINA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human tonsil, hepatocellular carcinoma, or histiocytoma
- Cellular Location: Cytoplasm
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
Deficiency in Alpha-1-AT can lead to chronic obstructive lung disease (emphysema) and, less frequently, hepatic cirrhosis in infants and respiratory distress in newborns.
Increased Alpha-1-AT levels are observed as an acute-phase response to tissue necrosis and inflammation. Elevated serum levels are associated with rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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