Thermo Fisher Scientific Alpha-1-Antitrypsin (SERPINA1) Monoclonal Antibody (AAT, 1378)
인간 Alpha-1-Antitrypsin(SERPINA1)을 인식하는 Mouse 단클론 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. Protein A/G 정제, PBS buffer에 0.05% BSA 및 sodium azide 포함, 4°C 보관. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AAT, 1378 |
| Immunogen | Recombinant human Alpha-1-Antitrypsin (AAT) protein fragment (amino acids 41–179) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For IHC on PFA-fixed tissues: incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of Alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema), hepatic cirrhosis in infants, and respiratory distress in newborns.
Increased Alpha-1-AT levels occur as an acute-phase response to tissue necrosis and inflammation. Elevated serum levels are observed in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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