Thermo Fisher Scientific Human CRIM2 Synthetic Peptide
인간 CRIM2 단백질의 카르복시 말단 근처 15개 아미노산 서열을 기반으로 한 합성 펩타이드. 블로킹 펩타이드로 사용 가능하며, BMP 신호전달 연구에 활용. 고순도 액상 형태로 제공되며 -20°C 보관.
- 카탈로그번호
- PEP1453
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to a 15-amino-acid sequence near the carboxy terminus of human CRIM2.
PEP-1453 can be used as a blocking peptide with polyclonal antibody PA5-34411.
Target Information
CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen important for kidney development and repair after acute kidney injury, enhancing its receptor binding.
Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury.
CRIM2 can also interact directly with activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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