Thermo Fisher Scientific Human Caspase 3 Synthetic Peptide
Human Caspase-3 중심부 17개 아미노산 서열을 포함한 합성 펩타이드입니다. PA5-34413 항체의 블로킹 펩타이드로 사용됩니다. 순수 정제된 액상 형태로 제공되며, PBS 버퍼에 0.1% BSA와 0.02% sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to a 17 amino acid sequence near the center of human Caspase-3.
PEP-1455 can be used as a blocking peptide with polyclonal antibody PA5-34413.
Target Information
The CASP3 gene encodes a protein that belongs to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis.
Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce large and small subunits. These subunits dimerize to form the active enzyme.
Caspase-3 cleaves and activates caspases 6, 7, and 9, and is itself processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, associated with neuronal death in Alzheimer’s disease.
Alternative splicing of this gene results in two transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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