Thermo Fisher Scientific PDCD1 Monoclonal Antibody (UMAB199), UltraMAB
PDCD1 (PD-1/CD279) 단백질을 인식하는 UMAB199 단클론 항체로, Human, Mouse, Rat, Dog에 반응합니다. Western blot, IHC, ICC/IF, ChIP assay 등 다양한 응용에 적합하며, 고순도 Affinity chromatography 정제 및 안정적 PBS/BSA/glycerol 포뮬러로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ChIP assay (ChIP) | Assay-dependent |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB199 |
| Immunogen | Full-length human recombinant protein of human PDCD1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express PD-1 (PDCD-1), which mediates inhibitory signals from APCs. PD-1 binds two ligands, PDL-1 and PDL-2, and inhibits immune activation in the absence of danger signals such as LPS. PD-1 deficiency leads to hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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