Thermo Fisher Scientific PDCD1 Monoclonal Antibody (UMAB199), UltraMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

T lymphocytes initiate cell-mediated immune responses upon stimulation by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express inhibitory receptors such as PD-1 (also known as PDCD-1), which bind to ligands PDL-1 and PDL-2 to downregulate immune activation.
In the absence of danger signals (e.g., LPS), PD-1 signaling suppresses T-cell activation. PD-1 knockout mice exhibit hyperactive immune systems and autoimmune disorders.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.