Thermo Fisher Scientific Phospho-JAK2 (Tyr972) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Product is stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

A BLAST analysis suggests cross-reactivity with human, orangutan, rat, and pig based on 100% sequence homology.
Cross-reactivity with JAK II from other sources has not been determined.

Target Information

Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is mutated in polycythemia vera.
This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to regulate gene transcription, including interferon-stimulated genes.
JAK2 is required for IFN gamma-receptor complex initiation, with JAK1 functioning as an amplifier.
Mutations in JAK2 are associated with Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, Myelofibrosis, and Acute myelogenous leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.