Thermo Fisher Scientific AURKB Monoclonal Antibody (6A6)
인간 AURKB 단백질을 특이적으로 인식하는 Mouse IgG1 단클론 항체. Western blot 및 ELISA에 적합하며, 액상 형태로 제공. 연구용으로만 사용 가능하며 -20°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6A6 |
| Immunogen | AURKB (AAH09751, 1–90 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN
Target Information
Aurora kinases associate with microtubules during chromosome movement and segregation.
AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers.
This complex functions in chromosome alignment and separation, histone modification, and cytokinesis.
The Chromosomal Passenger Complex (CPC) includes three non-enzymatic subunits: INCENP, survivin, and borealin, which regulate the activity, localization, and stability of AurB.
Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB.
AurB is overexpressed in various tumors, including breast and colon cancers, and may be linked with Aurora-A kinase through feedback regulation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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