Thermo Fisher Scientific AURKB Monoclonal Antibody (5H7)
AURKB 단백질을 인식하는 Mouse monoclonal antibody(클론 5H7)로, Western blot과 ELISA에 적합합니다. Human 시료에 반응하며, 액상 형태로 제공됩니다. -20°C에서 보관하며 동결-해동 반복을 피해야 합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H7 |
| Immunogen | AURKB (AAH09751, 1–90 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN
Target Information
Aurora kinases associate with microtubules during chromosome movement and segregation.
AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis.
The Chromosomal Passenger Complex (CPC) also includes three non-enzymatic subunits — INCENP, survivin, and borealin — which determine the activity, localization, stability, and substrate specificity of Aurora B.
Two CPCs exist during mitosis:
- One containing all four members (AurB, INCENP, survivin, borealin)
- Another consisting of INCENP and AurB
The full CPC functions during chromosome alignment and cytokinesis, while the INCENP–AurB complex may be responsible for histone H3 modification.
AurB is overexpressed in several tumors, including primary breast and colon samples, and its expression correlates with Aurora-A kinase, suggesting a feedback mechanism.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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