Thermo Fisher Scientific Calprotectin/MRP14/S100A9/Calgranulin B Monoclonal Antibody (S100A9/7553)
Calprotectin/MRP14/S100A9 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체입니다. 인간 시료에 반응하며 IHC(P)에서 1–2 µg/mL로 사용됩니다. 세포질 및 세포 표면 위치 확인에 유용하며 염증 관련 연구에 적합합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S100A9/7553 |
| Immunogen | Recombinant fragment (around aa1–100) of human S100A9 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Liver or histiocytoma
- Cellular Location: Cytoplasm, extracellular (secreted), cell surface
Target Information
The S100A8/A9 heterocomplex, also known as MRP-8/MRP-14 complex or calprotectin, comprises approximately 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages, and ileal tissue eosinophils.
Peripheral blood monocytes carry the antigen extra- and intracellularly, while neutrophils carry it only intracellularly.
The S100A8/A9 complex exhibits antibacterial, antifungal, immunomodulating, and antiproliferative effects, and acts as a potent chemotactic factor for neutrophils.
Plasma concentrations are elevated in diseases associated with increased neutrophil activity, such as inflammatory bowel disease.
Calprotectin is detectable in feces and elevated levels have been observed in body fluids (plasma, saliva, gingival crevicular fluid, stools, synovial fluid) during infection and inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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