Thermo Fisher Scientific Calprotectin/MRP14/S100A9/Calgranulin B Monoclonal Antibody (S100A9/7553)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Liver or histiocytoma
• Cellular Location: Cytoplasm, extracellular (secreted), cell surface

Target Information

The S100A8/A9 heterocomplex, also known as MRP-8/MRP-14 complex or calprotectin, comprises approximately 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages, and ileal tissue eosinophils.
Peripheral blood monocytes carry the antigen extra- and intracellularly, while neutrophils carry it only intracellularly.
The S100A8/A9 complex exhibits antibacterial, antifungal, immunomodulating, and antiproliferative effects, and acts as a potent chemotactic factor for neutrophils.
Plasma concentrations are elevated in diseases associated with increased neutrophil activity, such as inflammatory bowel disease.
Calprotectin is detectable in feces and elevated levels have been observed in body fluids (plasma, saliva, gingival crevicular fluid, stools, synovial fluid) during infection and inflammatory conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.