Thermo Fisher Scientific Calprotectin/MRP14/S100A9/Calgranulin B Monoclonal Antibody (CAGB/426)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises approximately 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages, and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, while neutrophils only intracellularly. The S100A8/A9 complex has antibacterial, antifungal, immunomodulating, and antiproliferative effects. It is also a potent chemotactic factor for neutrophils.

Plasma concentrations are elevated in diseases associated with increased neutrophil activity, such as inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall; therefore, calprotectin is detectable in feces. Elevated levels of calprotectin have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.