Thermo Fisher Scientific Phospho-ROR1 (Tyr786) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of ROR1 only when phosphorylated at Tyr786.

Target Information

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival.
It is virtually absent from normal pediatric and adult tissues, except for low-level expression in immature B-cell precursors (hematogones) and adipocytes.
ROR1 is notably overexpressed and considered a survival factor in several malignancies, including:

• Chronic lymphocytic leukemia (CLL)
• Mantle cell lymphoma (MCL)
• Acute lymphoblastic leukemia (ALL)
• Marginal zone lymphoma
• Lung adenocarcinoma

Initially identified in a neuroblastoma cell line during tyrosine kinase screening, ROR1 and its related receptor ROR2 were classified as orphan receptors due to unknown ligands.
Wnt-5a has since been suggested as a candidate ligand, and ROR1 functions as a pseudokinase promoting proliferation and apoptosis resistance in cancer cells through interaction with Wnt-5a and TCL1-mediated AKT co-activation.
ROR1 is expressed as a glycoprotein containing extracellular Ig-like, Frizzled, and Kringle domains, and an intracellular tyrosine kinase domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.