Thermo Fisher Scientific Phospho-TGFBR1 (Thr204) Polyclonal Antibody
Phospho-TGFBR1 (Thr204) 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 IHC(P)에서 사용 가능하며, 인산화된 Thr204 부위만 특이적으로 인식합니다. 1 mg/mL 액상 형태로 제공되며, -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TGFBR1 (Accession P36897), corresponding to amino acid residues around phosphorylated Thr204. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817553 |
Product Specific Information
This antibody detects endogenous levels of TGFBR1 only when phosphorylated at Thr204.
Target Information
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-β, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation, leading to downstream phosphorylation of SMADs by TGFBR1.
TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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