Thermo Fisher Scientific IkB beta Polyclonal Antibody
IKB beta 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합. 인간 반응성, 토끼 IgG 호스트, 액상 형태로 제공. 항원 친화 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human IKB beta (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2735953 |
Product Specific Information
- Positive Control: Target recombinant protein
- Predicted Reactivity: Mouse (84%), Rhesus Monkey (97%), Bovine (83%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB.
The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is carried out by three tightly associated IKK subunits: IKK alpha and IKK beta (catalytic subunits) and IKK gamma (regulatory subunit).
Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK beta (Ser176 and Ser180 in IKK alpha), which causes conformational changes, resulting in kinase activation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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