Thermo Fisher Scientific TNFAIP3 Monoclonal Antibody (59A426)
TNFAIP3(A20) 단백질을 인식하는 Mouse Monoclonal Antibody(59A426). Western blot, IHC, ICC, Flow, IP 등 다양한 응용에 적합. Human, Mouse, Rat에 반응하며 Protein G 정제. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg/mL |
| Immunoprecipitation (IP) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 59A426 |
| Immunogen | Full length recombinant human A20 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537683 |
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region frequently deleted in B cell lymphomas. It functions as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 encodes a zinc-finger protein rapidly induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity. Overexpression of TNFAIP3 also inhibits TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting its role as a negative regulator of TLR-mediated inflammatory responses. At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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